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Description
The cardiovascular evidence gap matters in two directions: it is a hard advantage for semaglutide on documented benefit, and an unknown for retatrutide that the glucagon-receptor arm makes worth watching specifically (glucagon-agonist effects on heart rate and metabolic rate are documented but the long-term MACE signal is open)
These usually go away as your body adjusts
The comparison between injectable and oral peptides provides broader context on these delivery methods
In 2024, Toms et al
