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Similarly, chitosan-modified PLGA NPs co-encapsulating liraglutide and alogliptin normalized glycemia for 24 h post-oral administration in STZ-induced diabetic rats, underscoring improved glucose regulation and the translational promise of non-invasive delivery routes [416]

Understanding this relationship is fundamental to all peptide dosage conversions

Of note, it has been shown that liraglutide improves learning and memory as well as cognitive function by regulating intracellular calcium homeostasis in cortical or hippocampal pyramidal cells (Wang et al., 2013)

The co-expression of GLP-1R, glucokinase, and glucose transporter protein 2 (GLUT-2) in the neurons involved in the control of food intake suggests that these cells may play a role in glucose sensing in the brain [14, 16-19]
