flow semaglutide clinical trial in Patients with Obesity-Related Heart Failure and Type 2 Diabetes FLOWing with the SemagluTIDE —
Description
Vagalvagal reflexes are activated by injection of a GLP-1R agonist into the hepatic portal vein, and they are measurable as increased electrical activity in vagal sensory afferent neurons and also in vagal efferent neurons

Madan S, et al

Characteristics that influence the ability of peptides to cross the BBB include: Size: The BBB selectively allows molecules of a certain size to pass through, typically only permitting small molecules

*Weight loss results are from separate clinical studies and should not be interpreted as a direct comparison due to differences in study design, populations and duration