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Oncogene 30 (24), 27302740

28 A landmark pilot study that investigated the efficacy and safety of 72-h GLP-1 RA infusion in patients with acute MI and impaired LVEF ( 12 weeks) to non-diabetic, overweight or obese individuals with HF (NYHA Class IIIII) and LVEF below 40%

Here, we present a review of the current literature surrounding the mechanisms of GLP-1 activity on glycogen metabolism, energy expenditure, and the relevant systems that interplay in inducing these states that can potentially explain the decreases in body weight seen in patients taking GLP-1 agonists, with effects summarized in Figure 1 [6]

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