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Despite metformins ability to lower glucose levels by boosting GLP-1 secretion in living organisms, it did not have the same effect on GLP-1 secretion in L cells during laboratory experiments ( 2.3 Alteration of the gut microbiota With the emergence of advanced sequencing technologies, it has become apparent that metformin mitigates the imbalance in gut microbiota associated with T2DM and its subsequent impact on host metabolism

However, emerging research and theories are beginning to shed light on potential overlaps