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These include: Hyperpigmentation Pale, dull-looking skin Vitiligo Psoriasis Eczema Acne can indicate low B12 levels
doi: 10.1038/nrclinonc.2016.60 31 KoppulaPZhuangLGanB

The FDA does not "approve" dietary supplements in the same way it does prescription drugs

Secondly, existing treatments primarily focus on lipid-lowering or antithrombotic effects but fail to address other key aspects of atherosclerotic pathology, including chronic inflammation and immune dysregulation