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Allow the initial dose to establish baseline response before making adjustments

This process was repeated three to four times including fresh perchloric acid and the final volume was made up to 100 mL

Following increased permeability of the BBB, extravasated albumin is taken up into astrocytes (73), resulting in impaired buffering of potassium and glutamate, which may cause neuronal hyperexcitability and spontaneous seizures (74)

In further support of this, Spearman correlation analysis indicated that although there was no significant correlation between the 2- and 4-hydroxyestrogens and the 4-hydroxyestrogen DNA-adducts or glutathione conjugates, the nature of the relationship between these metabolites changed from positive in the control women to negative in the COC users (Fig