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Description
Environmental toxins such as heavy metals and polycyclic aromatic hydrocarbons can disrupt histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity, causing changes in chromatin compaction that either repress or activate oncogenic gene expression [43,44,45]
The chamber is designed to separate the luminal side from the basolateral side of the epithelium and, to assess permeability, molecules are placed in the luminal chamber, and the flux of these markers to the basolateral side is measured as an indicator of permeability of the epithelium [41]
Visualization, protein quantification and result expression were identical as protein detection in tissue homogenates (above)
Williams, B.L., et al
