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312 Interestingly, existing studies showed that besides the acknowledged inhibitory effects on CS, baricitinib can also dampen ACE2-mediated SARS-CoV-2 endocytosis by inhibiting AP2-associated protein kinase 1 and cyclin G-associated kinase, 313,314 which serves as another mechanism of its action in COVID-19

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In addition, we elaborate on studies that have led to approval of the first FcRn antagonists, the clinical progress and structural design of molecules in the pipeline, their position in the overall therapeutic landscape of autoimmunity, the design of next-generation antagonists as well as the use of this receptor-targeting principle for other therapeutic applications