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found in their study that in clear cell renal cell carcinoma (ccRCC) tumor cells, endogenous Gln metabolism might reduce the anti-tumor effectiveness of T cells by promoting the Treg cell response ( 2.1.4 Regulation of tumor cell redox homeostasis Gln regulates the redox status of cancer cells by influencing the production of mitochondrial ROS

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MacDonald KG, Hoeppli RE, Huang Q, Gillies J, Luciani DS, Orban PC, et al

Abbreviations 18HEPE 18hydroxyeicosapentaenoic acid MHC myosin heavy chain ADP adenosine diphosphate ANP atrial natriuretic factor BAs bile acids BP blood pressure CDCA chenodeoxycholic cid CHD coronary heart disease CKD chronic kidney disease CNS central nervous system cPLA2a cytosolic phospholipase A2a CVDs cardiovascular diseases CYP7A1 cholesterol 7ahydroxylase DMB 3,3dimethyl1butanol DOCA deoxycorticosterone acetate ECCs enterochromaffin cells ECM extracellular matrix FFAR free fatty acid receptors FMT fecal microbiota transplantation FXR Farnesoid X Receptor GALT gutassociated lymphoid tissue GLP1 glucagonlike peptide1 GPCR Gproteincoupled receptors HF heart failure HFpEF heart failure with preserved ejection fraction HFrEF heart failure with reduced ejection fraction IAA indole3acetic acid IBD inflammatory bowel disease ICAM1 intercellular adhesion molecule1 ImP imidazole propionate IMT intimamedia thickness IPA indole3propionic acid IS indoxyl sulfate LCA lithocholic acid LPS lipopolysaccharides LXR Liver X Receptor mtROS mitochondrial reactive oxygen NAFLD nonalcoholic fatty liver disease NLRP3 nucleotidebinding oligomerization domain (NOD)like receptor protein 3 NO nitric oxide oxLDL oxidized LDL PAGln phenylacetyl glutamine PCS pcresol sulfate Phe phenylalanine PKC protein kinase C PRRs pattern recognition receptors PXR Pregnane X Receptor RAAS reninangiotensinaldosterone system RCT reverse cholesterol transport ROS reactive oxygen species SCFARs shortchain fatty acids receptors SCFAs shortchain fatty acids SHR spontaneously hypertensive SIRT3 sirtuin 3 T2D type 2 diabetes TAC transverse aortic constriction TGF transforminggrowth factor TGR5 Takeda G proteincoupled Receptor 5 TLR4 TollLike receptor 4 TMAO trimethylamine Noxide Trp tryptophan Tyr tyrosine VCAM1 vascular cell adhesion molecule1 VDR vitamin D receptor VECs vascular endothelial cells VSMCs vascular smooth muscle cells 1