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Examples of genetic defects inducing redox dysregulation and hemolytic anemia are the genetic deficiency of G6PDH (well-characterized human disease) and the genetic deficiency of antioxidant enzymes, including SOD1 and 2, Prx1 and 2, and nuclear factor E2-related factor 2 (Nrf2, a transcription factor controlling expression of multiple antioxidant and detoxifying enzymes)
Factors such as skin type, melanin production, lifestyle, dosage, and overall health play a role in the speed of skin whitening
