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[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Gawrieh S., Chalasani N

Oxidative stress, characterized by an imbalance between the production of ROS and antioxidant defenses, can trigger various inflammatory pathways, including the nuclear factor kappa B (NF-B) signaling pathway

This leakage further activates microglia towards the M1 phenotype, promoting release of neurotoxic agents, including TNF- and IL-6 (50)

As a prevalent peripheral vascular disease, LL-IRI results in local tissue damage and triggers systemic inflammatory responses that can lead to multiple-organ dysfunction syndrome, as well as multiorgan failure and death in severe cases