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Since its approval, 13 analogs have been evaluated in clinical trials, but only one, carboplatin, has achieved worldwide acceptance, due to its reduced side-effects, although being less effective, with the clinical standard dosage of carboplatin being a 4:1 ratio compared to cisplatin 23

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Although mechanistic links between iron regulation and cholesterol levels are evident in mice [127], further work should explore how altered iron influences cholesterol metabolism in humans

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