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36,37 Zonula occludens (ZO), including ZO-1 and its homologs ZO-2 and ZO-3, is a group of PDZ-related scaffolding proteins that belong to the superfamily of membrane-associated guanylate kinase-like proteins, possessing sites of three tandem PDZ domains at the N-terminus 38,39 (Figure 1)

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Nature medicine, 2018;doi:10.1038/s41591-018-0092-9

Since CTR receptors also couple with multiple G proteins (e.g., Gs, Gq, Gi/o), the AMY receptors could also modulate the activation of various kinases (including ERK1/2 and FAK) [19,52]