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The binding domain structure of GH receptors in ice age animals may be more compact, with changes in the arrangement and length of secondary structures in certain regions, such as alpha helices and beta folds

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For example, chronic exposure (1727 months) in rhesus monkeys to clinically-relevant dosages of olanzapine and haloperidol resulted in an 8% volume reduction in gray and white matter across most brain regions [143]

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