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CB-1158 could block myeloid cell-mediated inhibition of T cell proliferation, increase the number of tumor-infiltrating CD8 + T cells and NK cells, and increase the expression of inflammatory factors and interferon-, thereby changing the immune microenvironment to promote inflammation and reduce tumor immune escape, inhibiting tumor cell proliferation
I., Dzugkoeva F
Gherardi G et al
Critically, polypharmacy interactions demand coordinated management (Table S8): Statins deplete coenzyme Q10, impairing OXPHOS and increasing ferroptosis risk, necessitating CoQ10 supplementation (~100 mg/day) [286]
