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It influences local repair biology

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Consistent with the role as a second hit, MAPK are known to be activated by oxidative stress and have been involved in APAP hepatotoxicity

Clin Chem 44:679681 Noureddin M, Sander-Struckmeier S, Mato JM (2020) Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: a systematic review
