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The primary source of data was the PubMed database, accessing articles published between January 1980 and May 2025

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Fluoxetine (Prozac, Sarafem), a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI) can cause low levels of melatonin in people In an animal study, melatonin supplements reduced the antidepressant effects of fluoxetine (Prozac, Sarafem) and desipramine (Norpramin), a type of antidepressant called a tricyclic It is unknown if these same effects would occur in humans Combining medications or supplements that both work to increase serotonin levels can cause serotonin to accumulate and reach abnormally high levels in the body, resulting in a serious condition called serotonin syndrome, which can cause shivering, fever, diarrhea, muscle rigidity, or seizures If you take any kind of antidepressant, talk to your doctor before using melatonin supplements

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