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Although some transport of glutathione S -conjugates may occur across the sinusoidal membranes (e.g., Inoue et al., 1984a, Inoue et al., 1984b), the major route for the removal of these compounds in the rat liver is via canicular transporters into the bile (e.g., Akerboom et al., 1991, Hinchman et al., 1998, Keppler and Knig, 2000, Vore, 1993)

The tissue injury associated with OTA was accompanied by a disruption of pathways related to the transcription factors hepatocyte nuclear factor 4 alpha (HNF4) and nuclear factor-erythroid 2-related factor 2 (Nrf2) [73]

Within weeks, many patients notice decreased pain, improved stability, and increased range of motion

However, it is thought that this disease could be caused by an infection in the bees' gut caused by the fungus Nosema ceranae, which often causes enormous damage and the death of entire colonies of bees