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Introduction Rett syndrome (RTT, OMIM 312750) is a neurodevelopmental disorder that primarily affects girls and is usually caused by mutation in the X-linked gene Methyl-CpG-binding Protein 2 ( MECP2 ) (Neul et al., 2008)

Among the pro-ferroptotic regulators, ACSL4 acts as a decisive hub by catalyzing the formation of PUFA-CoAs, thereby supplying the essential substrates for lipid peroxidation

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