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glutathione makes me poop - The Amazing Detoxification Molecule You Might Not Know Current Insights into Glutathione Depletion
Description
this may be because NMN first requires dephosphorylation into NR before uptake into cells 39

doi: 10.7762/cnr.2014.3.2.75 15

In other systems, canonical Wnt signaling synergizes with TGF signaling to enhance fibrotic responses (262, 263), and this pathway is first activated in LECs at 12 hours PLI and is found in most if not all fibrotic capsule associated cells (CACs) at 5 and 9 days PLI (261)
Because of much higher concentration levels in intravenous dosing coupled with the recirculation of compound in several sites in series, it is estimated that first-pass elimination (or presystemic metabolism) is in effect