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Thats because methotrexate attacks fast-dividing cells, which include cancer cells
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Biomaterials 196, 8089
Butyrate acts through a stimulation of peroxisome proliferator-activated receptor- coactivator 1 (PGC-1) activity, which results from the inhibition of HDAC and the activation of AMP-activated protein kinase (AMPK) [25]
