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10.1016/S0140-6736(14)61005-9 2

Dual glucagon like peptide 1 (GLP1) and glucose-dependent insulinotropic peptide (GIP) receptor agonists are among the new pharmacological strategies recently developed to address this challenge

This operation can be expressed equivalently in vector form as: where w T denotes the transpose of the weighting vector: For the present sampling protocol, where the intervals are 4 h, 5 h, and 7 h, this becomes: and therefore: This vector formulation is mathematically identical to trapezoidal integration of the circadian cortisol curve and makes explicit that the ASI profile represents a weighted temporal integration of hormone concentrations determined solely by the sampling schedule