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It was also reported that a considerable amount of GST, corresponding to 10% of the cytosolic pool, is electrostatically associated with the outer nuclear membrane, and a similar quantity is compartmentalized inside the nucleus [56]

An evaluation of pegvisomant as long-term monotherapy in acromegalic patients from the global safety surveillance study ACROSTUDY reported increases or increases/decreases in the tumor sizes in 12 of 542 subjects (2.2%)