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Further, low-grade inflammation associated with aging, chronic infections such as HIV, and autoimmune diseases such as MS and RA are all risk factors for developing depression, and patients with depression with increased inflammation may represent a relatively treatment-resistant population with increased risk for SUDs and suicide (Alexopoulos and Morimoto, 2011

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Green S., Chambon P

Senescent cells secrete the senescence-associated secretory phenotype (SASP), which consists of inflammatory cytokines and chemokine growth factors, into the surrounding tissues
[DOI] [PubMed] [Google Scholar] 82.Borkum J
