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On the other hand, the hypozincemia observed in patients with ME/CFS could occur due to increased proinflammatory cytokines in response to infection, as they increase the expression of zinc transporters and zinc-binding peptides, leading in the long term to a reduction in their availability in blood and their uptake by immune cells [328, 329, 372]

Mice were observed for 6 h after surgery, and were then transferred to an experimental animal center for standardized feeding

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