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116 , 395404 (2006) Ng, P
The cyclic lactam constraint between the Asp and Lys side chains preorganizes the conserved His-Phe-Arg-Trp (HFRW) message tetrapeptide of -MSH into the receptor-bound conformation, which is responsible for the dramatic potency increase relative to the linear native hormone
The authors would like to express their thanks to Mihoko Shimada, Department of Human Genetics, Graduate School of Medicine, The University of Tokyo for technical assistance
The epidermis is atrophic and the underlying dermis shows marked solar damage
