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By combining HDACi with chemotherapy drugs, it may be possible to significantly improve patients quality of life and reduce the overall toxicity burden of chemotherapy without compromising antitumor efficacy (87)

Notably, members of the defensin family such as HNP1, hBD2, hBD3, and hBD4 have been reported to induce keratinocyte proliferation and migration, which can then secrete hBDs, promoting cellular barrier reconstruction and accelerating wound healing
