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Description
We find that the hydrated proton forms a fluxional defect in the hydrogen-bonded network, with both H9O4+ and H5O2+ occurring only in the sense of 'limiting' or 'ideal' structures

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J Clin Gastroenterol 20(3):244247 Kidwell DA, Holland JC, Athanaselis S (1998) Testing for drugs of abuse in saliva and sweat

Nevertheless, it highlights the importance of future controlled trials involving larger cohorts to further understand Metformin in the context of neurodegeneration in non-diabetic aging individuals
