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The CortisolDetox Connection Chronic stress raises cortisol, suppresses immune function, and slows liver clearance

Even though some studies have shown that alveolar type II cells can supplement endogenous synthesis of GSH with the uptake of exogenous GSH (11, 12), the antioxidant effectiveness of exogenously administered GSH is hindered by its instability when crossing cell membranes and its rapid hydrolysis in the circulation (13-15)

doi: 10.1016/j.heliyon.2022.e09526

Particularly the heterodimer XPF-ERCC1, a rate-limiting factor for the NER pathway, that has single-strand DNA endonuclease activity and incises DNA on the 5 side of cisplatin adducts, and also participate in the repair of double-strand breaks induced by ICLs 11