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This atrophy leads to a reduction in sperm production and quality [90, 91]
Some scholars have discovered by knocking out the mouse SQSMT1 gene that SQSTM1 mediates ULK1 phosphorylation to activate autophagy and promote the formation of AMPK-ULK1-SQSTM1 complex, which leads to autophagic Keap1 degradation and activates the non-canonical Keap1-Nrf2 pathway, thereby protecting mouse liver from lipotoxicity (Figure 4) (Lee et al., 2020)
[11] and Lardinois [12]
Di Conza, G., Tsai, C.-H
