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Int J Immunopathol Pharmacol 30: 2543, 2017

Some retrospective studies suggest CPAP treatment may reduce the risk for cardiovascular events, but other observational studies and, most importantly, randomized clinical trials have not found a significant reduction in the frequency of cardiovascular events and CVD in obstructive sleep apnea with CPAP use

However, this variant is rare, and one should hesitate to make this diagnosis in an adult person unless the summary of findings (small size, sharp circumscription, good maturation of the dermal component) favors a nevus and the pagetoid spread shows some uniformity (usually limited to the lower part of the spinous cell layer, not asymmetrically localized to the edge of the lesion)

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